PUBLICATIONS
Sun H, Hobert O. Temporal transitions in post-mitotic neurons throughout the C. elegans nervous system. Nature 600(7887):93-99. (2021).
Isabella AJ, Leyva-Diaz e, Kaneko T, Gratz SJ, Moens CB, HobertO, O’Connor-Giles K, Thskur R, Sun H. The field of neurogenetics: where it stands and where it is going. Genetics 218(4):iyab085 (2021).
Berghoff EG, Glenwinkel L, Bhattacharya A, Sun H, Mohammadi N, Antone A, Feng Y, Nguyen K, Cook SJ, Wood JF, Masoudi N, Cros C, Ferkey DM, Hall DH, Hobert O. The Prop1-like homeobox gene unc-42 specifies the identity of synaptically connected neurons. Elife 10:e64903 (2021).
Bayer EA, Sun H, Rafi I, Hobert O. Temporal, Spatial, Sexual and Environmental Regulation of the Master Regulator of Sexual Differentiation in C. elegans. Curr Biol 30(18):3604-3616 (2020).
Anderson EM, Sun H, Guzman D, Taniguchi M, Cowan CW, Maze I, Nestler EJ, Self DW. Knockdown of the histone di-methyltransferase G9a in nucleus accumbens shell decreases cocaine self-administration, stress- induced reinstatement, and anxiety. Neuropsychopharmacology 44(8):1370-1376 (2019).
Iglesia BV, Aghayeva U, Sun H, Wang C, Glenwinkel L, Bayer E, Hobert O. An atlas of C. elegans chemoreceptor expression. PLoS Biol. 16(1):e2004218 (2018).
Sun H, Damez-Werno D, Scobie K, Shao N, Dias C, Rabkin J, Wright K, Mouzon E, Kabbaj M, Neve R, Turecki G, Shen L, Nestler EJ. Regulation of BAZ1A and nucleosome positioning in the nucleus accumbens in response to cocaine. Neuroscience. 353:1-6 (2017).
Damez-Werno DM, Sun H, Scobie KN, Shao N, Rabkin J, Dias C, Calipari ES, Maze I, Pena CJ, Walker DM, Cahill ME, Chandra R, Gancarz A, Mouzon E, Landry JA, Cates H, Lobo MK, Dietz D, Allis CD, Guccione E, Turecki G, Defilippi P, Neve RL, Hurd YL, Shen L, Nestler EJ. Histone arginine methylation in cocaine action in the nucleus accumbens. Proc Natl Acad Sci USA. 113(34): 9623-8 (2016).
Bagot RC, Cates HM, Purushothaman I, Lorsch ZS, Walker DM, Wang J, Huang X, Schlüter OM, Maze I, Peña CJ, Heller EA, Issler O, Wang M, Song WM, Stein JL, Liu X, Doyle MA, Scobie KN, Sun H, Neve RL, Geschwind D, Dong Y, Shen L, Zhang B, Nestler EJ. Circuit-wide Transcriptional Profiling Reveals Brain Region-Specific Gene Networks Regulating Depression Susceptibility. Neuron. 90(5): 969-83 (2016).
Sun H, Martin JA, Werner CT, Wang ZJ, Damez-Werno DM, Scobie KN, Shao NY, Dias C, Rabkin J, Koo JW, Gancarz AM, Mouzon EA, Neve RL, Shen L, Dietz DM, Nestler EJ. BAZ1B in Nucleus Accumbens Regulates Reward-Related Behaviors in Response to Distinct Emotional Stimuli. Journal of Neuroscience. 36(14): 3954-61 (2016).
Cahill ME, Bagot RC, Gancarz AM, Walker DM, Sun H, Wang ZJ, Heller EA, Feng J, Kennedy PJ, Koo JW, Cates HM, Neve RL, Shen L, Dietz DM, Nestler EJ. Bidirectional Synaptic Structural Plasticity after Chronic Cocaine Administration Occurs through Rap1 Small GTPase Signaling. Neuron. 89(3): 566-82 (2016)
Sun H, Damez-Werno D, Scobie K, Shao N, Dias C, Rabkin J, Koo JW, Korb E, Bagot R, Ahn FH, Cahill M, Labonte B, Mouzon E, Heller E, Cates H, Golden SA, Gleason K, Russo SJ, Andrews S, Neve R, Kennedy PJ, Maze I, Dietz DM, Allis CD, Turecki G, Varga-Weisz P, Tamminga C, Shen L, Nestler EJ. ACF chromatin remodeling complex mediates stress-induced depressive-like behavior. Nature Medicine. 21(10): 1146-53 (2015).
Dias C, Dietz D, Mazei-Robison M, Sun H, Damez-Werno D, Ferguson D, Wilkinson M, Magida J, Gao V, Neve R, Nestler EJ. Dishevelled-2 regulates cocaine-induced structural plasticity and Rac1 activity in the nucleus accumbens. Neurosci Lett. 598: 23-8 (2015)
Koo JW, Mazei-Robison MS, LaPlant Q, Egevari G, Braunscheidel KM, Adank DN, Ferguson D, Feng J, Sun H, Scobie KN, Damez-Werno D, Riberio E, Pena CJ, Walker D, Bagot RC, Cahill ME, Anderson SA, Labonte B, Hodes GE, Browne H, Chadwick B, Robison AJ, Vialou VF, Dias C, Lorsch Z, Mouzon E, Lobo MK, Dietz DM, Russo SJ, Neve RL, Hurd YL, Nestler EJ. Epigenetic basis of opiate suppression of Bdnf gene expression in the ventral tegmental area. Nature Neuroscience. 18(3): 415-22 (2015).
Dias C, Feng J, Sun H, Shao NY, Mazei-Robison MS, Damez-Werno D, Scobie K, Bagot R, Labonte B, Ribeiro E, Liu X, Kennedy P, Vialou V, Ferguson D, Pena C, Calipari ES, Koo JW, Mouzon E, Ghose S, Tamminga C, Neve R, Shen L, Nestler EJ. β-Catenin mediates stress resilience through Dicer1/microRNA regulation. Nature. 516(7529): 51-5 (2014).
Maze I, Shen L, Zhang B, Garcia BA, Shao N, Mitchell A, Sun H, Akbarian S, Allis CD, Nestler EJ. Analytical tools and current challenges in the modern era of neuroepigenomics. Nat Neurosci. 17(11): 1476-90 (2014). (Review)
Heller EA, Cates HM, Pena CJ, Sun H, Shao N, Feng J, Golden SA, Herman JP, Walsh JJ, Mazei-Robison M, Ferguson D, Knight S, Gerber MA, Nievera C, Han MH, Russo SJ, Tamminga CS, Neve RL, Shen L, Zhang HS, Zhang F, Nestler EJ. Locus-specific epigenetic remodeling controls addiction- and depression-related behaviors. Nature Neuroscience. 17(12): 1720-7 (2014).
Robison AJ, Vialou V, Sun H, Labonte B, Golden SA, Dias C, Turecki G, Tamminga C, Russo SJ, Mazei-Robison MS, Nestler EJ. Fluoxetine Epigenetically Alters the CaMKIIα Promoter in Nucleus Accumbens to Regulate ΔFosB Binding and Antidepressant Effects. Neuropsychopharmacology. 39(5): 1178-86 (2014).
Maze I, Chaudhury D, Dietz DM, Von Schimmelmann M, Kennedy PJ, Lobo MK, Sillivan SE, Miller ML, Bagot RC, Sun H, Turecki G, Neve RL, Hurd YL, Shen L, Han MH, Schaefer A, Nestler EJ. G9a controls neuronal subtype specification in striatum. Nature Neuroscience. 17(4): 533-9 (2014).
Scobie KN, Damez-Werno D*, Sun H*, Shao N, Gancarz A, Panganiban CH, Dias C, Koo J, Caiafa P, Kaufman L, Neve RL, Dietz DM, Shen L, Nestler EJ. Essential Role of Poly(ADP-ribosyl)ation in Cocaine Action. Proc Natl Acad Sci USA. 111(5): 2005-10 (2014).
Dietz DM*, Kennedy PJ*, Sun H*, Maze I, Gancarz AM, Vialou V, Koo JW, Mouzon E, Ghose S, Tamminga CA, Nestler EJ. ΔFosB induction in prefrontal cortex by antipsychotic drugs is associated with negative behavioral outcomes. Neuropsychopharmacology. 39(3): 538-44 (2014).
Walsh JJ, Friedman AK, Sun H, Heller EA, Ku SM, Juarez B, Burnham VL, Mazei-Robison MS, Ferguson D, Golden SA, Koo JW, Chaudhury D, Cristoffel DJ, Pomeranz L, Friedman JM, Russo SJ, Nestler EJ, Han MH. Stress and CRF gate neural activation of BDNF in the mesolimbic reward pathway. Nature Neuroscience. 17(1): 27-9 (2013).
Sun H, Kennedy PJ, Nestler EJ. Epigenetics of the depressed brain: role of histone acetylation and methylation. Neuropsychopharmacology. 38(1): 124-37 (2013). (Review)
Sun H, Maze I, Dietz DM, Scobie KN, Kennedy PJ, Damez-Werno D, Neve RL, Zachariou V, Shen L, Nestler EJ. Morphine epigenomically regulates behavior through alterations in histone H3 lysine 9 dimethylation in the nucleus accumbens. Journal of Neuroscience. 32 (48): 17454-64 (2012).
Koo JW, Mazei-Robison MS, Chaudhury D, Juarez B, LaPlant Q, Ferguson D, Feng J, Sun H, Scobie KN, Damez- Werno D, Crumiller M, Ohnishi YN, Ohnishi YH, Mouzon E, Dietz DM, Lobo MK, Neve RL, Russo SJ, Han MH, Nestler EJ. BDNF is a negative modulator of morphine action. Science. 338(6103): 124-8 (2012).
Damez-Werno D, LaPlant Q, Sun H, Scobie KN, Dietz DM, Walker IM, Koo JW, Vialou VF, Mouzon E, Russo SJ, Nestler EJ. Drug experience epigenetically primes Fosb gene inducibility in rat nucleus accumbens. Journal of Neuroscience. 32(30): 10267-72 (2012).
Dietz DM, Sun H, Lobo M, Cahill ME, Chadwick B, Gao V, Koo JW, Mazei-Robison M, Dias C, Maze I, Damez- Werno D, Dietz KC, Scobie KN, Ferguson D, Christoffel D, Ohnishi Y, Hodes GE, Zheng Y, Neve RL, Hahn KM, Russo SJ, Nestler EJ. Rac1 is essential in cocaine-induced structural plasticity of nucleus accumbens neurons. Nature Neuroscience. 15(6): 891-6 (2012).
Sun H, Cocker PJ, Zeeb FD, Winstanley CA. Chronic atomoxetine treatment during adolescence decreases impulsive choice, but not impulsive action, in adult rats and alters markers of synaptic plasticity in the orbitofrontal cortex. Psychopharmacology. 219(2): 285-301 (2012). *
Covington HE 3rd, Maze I, Sun H, Bomze HM, DeMaio KD, Wu EY, Dietz DM, Lobo MK, Ghose S, Mouzon E, Neve RL, Tamminga CA, Nestler EJ. A role for repressive histone methylation in cocaine-induced vulnerability to stress. Neuron. 71(4): 656-70 (2011).
Maze I, Feng J, Wilkinson MB, Sun H, Shen L, Nestler EJ. Cocaine dynamically regulates heterochromatin and repetitive element unsilencing in nucleus accumbens. Proc Natl Acad Sci USA. 108 (7): 3035-40 (2011).
Lobo MK, Covington HE 3rd, Chaudhury D, Friedman AK, Sun H, Damez-Werno D, Dietz DM, Zaman S, Koo JW, Kennedy PJ, Mouzon E, Mogri M, Neve RL, Deisseroth K, Han MH, Nestler EJ. Cell type-specific loss of BDNF signaling mimics optogenetic control of cocaine reward. Science. 330(6002):385-90 (2010).
Sun H, Green TA, Theobald DE, Birnbaum SG, Graham DL, Zeeb FD, Nestler EJ, Winstanley CA. Yohimbine increases impulsivity through activation of cAMP response element binding in the orbitofrontal cortex. Biol Psychiatry. 67(7): 649-56 (2010).
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